Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media

Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media

Modern iodinated radiocontrast media are all based on the triiodinated benzene ring with various chemical modifications having been made over the last few decades in order to reduce their toxicity. However, CIN remains a problem especially in patients with pre-existing renal failure. In vitro studies have demonstrated that all RCM are cytotoxic. RCM administration in vivo may lead to a decrease...

Cellular and molecular mechanisms of cyclosporin nephrotoxicity.

Cyclosporin therapy is associated with several forms of nephrotoxicity, the most significant of which are reversible impairment of glomerular filtration and irreversible interstitial fibrosis. Impaired glomerular filtration is due to both reduction in Kf, the glomerular capillary ultrafiltration coefficient, and to reduction in renal blood flow. The mechanisms responsible for the low Kf are not...

O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma

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Types of Radiocontrast Media

Acute Nephrotoxicity of Cisplatin: Molecular mechanisms Authors

Nephrotoxic drugs are responsible for approximately 20% of the episodes of acute kidney injury (AKI) in hospital and outpatient settings. Among elderly individuals, the incidence of drug-induced nephrotoxicity can be as high as 66%. Cisplatin (cis-diamminedichloroplatinum II CDDP) is an oncologic medication included in most chemotherapy regimens for solid or hematologic tumors. Cisplatin’s anti...